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Expression of steroidogenic enzymes in human placenta according to the gestational age.
Hong SH, Kim SC, Park MN, Jeong JS, Yang SY, Lee YJ, Bae ON, Yang HS, Seo S, Lee KS, An BS. Hong SH, et al. Mol Med Rep. 2019 May;19(5):3903-3911. doi: 10.3892/mmr.2019.10048. Epub 2019 Mar 15. Mol Med Rep. 2019. PMID: 30896833
The mRNA and protein expression of CYP17A1, HSD17B3 and CYP19A1, which are associated with the synthesis of dehydroepiandrosterone (DHEA) and E2, was elevated at different gestational ages in human placenta. In addition, to evaluate the correlation between serum and …
The mRNA and protein expression of CYP17A1, HSD17B3 and CYP19A1, which are associated with the synthesis of dehydroepiandrosterone (D …
Ameliorative effect of ginseng extract on phthalate and bisphenol A reprotoxicity during pregnancy in rats.
Saadeldin IM, Hussein MA, Suleiman AH, Abohassan MG, Ahmed MM, Moustafa AA, Moumen AF, Abdel-Aziz Swelum A. Saadeldin IM, et al. Environ Sci Pollut Res Int. 2018 Jul;25(21):21205-21215. doi: 10.1007/s11356-018-2299-1. Epub 2018 May 18. Environ Sci Pollut Res Int. 2018. PMID: 29777495
Determination of serum sex hormones (testosterone, progesterone, and estradiol) were determined on days 4, 10, and 20 of pregnancy. mRNA transcripts of STAR, HSD17B3, CYP17, AKT1, and PTEN were relatively quantified against ACTB in the ovary and placenta of days 10 …
Determination of serum sex hormones (testosterone, progesterone, and estradiol) were determined on days 4, 10, and 20 of pregnancy. mRNA tra …
Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy.
O'Shaughnessy PJ, Monteiro A, Bhattacharya S, Fraser MJ, Fowler PA. O'Shaughnessy PJ, et al. Mol Hum Reprod. 2013 Mar;19(3):177-87. doi: 10.1093/molehr/gas059. Epub 2012 Nov 29. Mol Hum Reprod. 2013. PMID: 23197595
The human feto-maternal unit produces large amounts of steroid hormones, particularly estrogens, during the second and third trimesters. The fetal adrenal gland and the placenta are considered the principal tissues driving steroid production but the fetal liver is likely t …
The human feto-maternal unit produces large amounts of steroid hormones, particularly estrogens, during the second and third trimesters. The …
Targeted placental deletion of OGT recapitulates the prenatal stress phenotype including hypothalamic mitochondrial dysfunction.
Howerton CL, Bale TL. Howerton CL, et al. Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9639-44. doi: 10.1073/pnas.1401203111. Epub 2014 Jun 16. Proc Natl Acad Sci U S A. 2014. PMID: 24979775 Free PMC article.
Therefore, we generated a transgenic mouse with targeted placental disruption of Ogt (Pl-OGT) and examined offspring for recapitulation of the adult EPS phenotype. Pl-OGT hemizygous and EPS male placentas showed similar robust changes in gene expression patterns suggestive …
Therefore, we generated a transgenic mouse with targeted placental disruption of Ogt (Pl-OGT) and examined offspring for recapitulation of t …